Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.44 |
| ▸ | JAK2 | O60674 | 17/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16989670 | 0.80 | JAK1 (0.48) | JAK1JAK2 | |
| SCHEMBL19953558 | 0.76 | USP2 (0.52) | JAK1JAK2 | |
| SCHEMBL29187312 | 0.74 | JAK1 (0.45) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL9921830 | 0.71 | MEN1 (0.44) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL346150 | 0.71 | JAK1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL26148291 | 0.70 | MEN1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL21775669 | 0.70 | JAK1 (0.42) | JAK1JAK2 | |
| SCHEMBL14964522 | 0.70 | JAK1 (0.55) | JAK1JAK2 | |
| SCHEMBL22989493 | 0.70 | JAK1 (0.45) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL25270241 | 0.69 | MEN1 (0.45) | JAK1JAK2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105226-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | Incyte Corporation (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123424-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | INCYTE CORPORATION (US) | 2015-08-20 | — | — | WO | disclosed |