SCHEMBL21775669

SCHEMBL21775669

CC(C)(C)OC(=O)N1CC(CC#N)(N2CCC3(CC2)OCCO3)C1

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
JAK1 P23458 18/20 0.42
JAK2 O60674 16/20 0.42
USP2 O75604 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19953558 0.85 USP2 (0.52) JAK1JAK2USP2SMN1; SMN2
SCHEMBL29187312 0.82 JAK1 (0.45) JAK1JAK2
SCHEMBL16989670 0.80 JAK1 (0.48) JAK1JAK2
SCHEMBL2077067 0.77 USP2 (0.59) USP2SMN1; SMN2
SCHEMBL21784364 0.76 KDM1A (0.39) JAK1JAK2
SCHEMBL31479119 0.74 USP2 (0.47) JAK1JAK2USP2SMN1; SMN2
SCHEMBL10062603 0.74 USP2 (0.49) USP2SMN1; SMN2
SCHEMBL18655778 0.73 USP2 (0.46) USP2SMN1; SMN2
SCHEMBL9921830 0.71 MEN1 (0.44) JAK1JAK2USP2SMN1; SMN2
SCHEMBL20347009 0.71 USP2 (0.56) USP2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11512064-B2 Salts of an LSD1 inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2022-11-29 US disclosed
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION 2021-09-30 US disclosed
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2021-04-06 US disclosed
WO-2020047198-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION (US) 2020-03-05 WO disclosed
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME WILMINGTON PHARMATECH 2020-03-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11512064-B2 Salts of an LSD1 inhibitor and processes for preparing the same KDM1A, KDM1B, KDM2A JAK1 864/4885JAK2 441/4885USP2 357/4885
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A JAK1 864/4885JAK2 441/4885USP2 357/4885
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A JAK1 864/4885JAK2 441/4885USP2 357/4885
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same KDM1A, KDM1B, KDM2A JAK1 864/4885JAK2 441/4885USP2 357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.