Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 16/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17009572 | 1.00 | GPR6 (0.48) | GPR6MKNK1MKNK2CYP2D6IRAK4 | |
| SCHEMBL15566210 | 0.86 | GPR6 (0.50) | GPR6CYP2D6PGK1 | |
| SCHEMBL17009593 | 0.82 | GPR6 (0.48) | GPR6CYP2D6 | |
| SCHEMBL17009563 | 0.78 | GPR6 (0.51) | GPR6 | |
| SCHEMBL17009559 | 0.78 | GPR6 (0.51) | GPR6 | |
| SCHEMBL17009562 | 0.78 | GPR6 (0.51) | GPR6 | |
| SCHEMBL17007727 | 0.74 | GPR6 (0.47) | GPR6PGK1 | |
| SCHEMBL16818337 | 0.74 | ALDH1A1 (0.42) | GPR6CYP2D6PGK1 | |
| SCHEMBL17009592 | 0.73 | GPR6 (0.43) | GPR6CYP2D6PGK1 | |
| SCHEMBL15566173 | 0.69 | GPR6 (0.39) | GPR6IRAK4PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105230-A1 | PYRIDOPYRAZINES MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123505-A1 | PYRIDOPYRAZINES MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-08-20 | — | — | WO | disclosed |