Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14064259 | 0.79 | KDM4E (0.47) | KMT2AMAPTRAB9ACYP1A2CYP2C19 | |
| SCHEMBL28928747 | 0.78 | HTT (0.42) | KMT2ASMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL26697204 | 0.72 | RECQL (0.44) | KMT2ASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL26907255 | 0.72 | RECQL (0.44) | KMT2ASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL24523038 | 0.70 | ALDH1A1 (0.46) | KMT2ASMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL21999716 | 0.69 | KMT2A (0.77) | KMT2ASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL10886210 | 0.68 | RECQL (0.50) | SMN1; SMN2MAPTCYP1A2CYP2C19RECQL | |
| SCHEMBL10872948 | 0.68 | CYP1A2 (0.40) | KMT2ACYP1A2CYP2C19RECQLALDH1A1 | |
| SCHEMBL16016268 | 0.68 | CYP2A6 (0.47) | KMT2ASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL9443772 | 0.67 | ALDH1A1 (0.43) | SMN1; SMN2MAPTNPC1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2731940-B1 | 4 - PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-19 | — | — | EP | disclosed |