Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 14/20 | 0.73 |
| ▸ | FYN | P06241 | 3/20 | 0.73 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12516852 | 0.90 | CHEK2 (0.88) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL4620246 | 0.85 | CHEK2 (1.00) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL18613241 | 0.85 | FYN (1.00) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL13977050 | 0.83 | CHEK2 (0.77) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL28051402 | 0.83 | CHEK2 (0.68) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL2228006 | 0.82 | CHEK2 (0.75) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL12077792 | 0.81 | CHEK2 (0.87) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL2224862 | 0.81 | CHEK2 (0.72) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL12078010 | 0.80 | MAP4K4 (0.79) | CHEK2FYNMKNK1MAP4K4CHEK1 | |
| SCHEMBL12078349 | 0.80 | CHEK2 (0.72) | CHEK2FYNMKNK1MAP4K4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526090-B1 | NEW ANTI-MALARIAL AGENTS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2015-08-19 | — | — | EP | disclosed |