Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.39 |
| ▸ | RXRA | P19793 | 8/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DDT | P30046 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211521 | 0.89 | ADRB2 (0.57) | ADRB2ALDH1A1KDM4EPOLBRAB9A | |
| SCHEMBL8209034 | 0.88 | ADRB2 (0.47) | ADRB2ALDH1A1KDM4EPOLBNPSR1 | |
| SCHEMBL8210993 | 0.88 | ADRB2 (0.46) | ADRB2ALDH1A1KDM4EPOLBKLKB1 | |
| SCHEMBL12853254 | 0.88 | HPGD (0.44) | ADRB2ALDH1A1KDM4EPOLBRAB9A | |
| SCHEMBL8206269 | 0.87 | ADRB2 (0.45) | ADRB2ALDH1A1KDM4EPOLBRAB9A | |
| SCHEMBL12853297 | 0.87 | DDT (0.53) | ADRB2ELANERAB9ANPSR1DDT | |
| SCHEMBL12853294 | 0.85 | KDM4E (0.44) | ADRB2ALDH1A1KDM4EPOLBNPSR1 | |
| SCHEMBL12853289 | 0.85 | KCNJ1 (0.46) | ADRB2ELANEALDH1A1KDM4EPOLB | |
| SCHEMBL8205788 | 0.85 | ADRB2 (0.43) | ADRB2ALDH1A1KDM4EPOLBKLKB1 | |
| SCHEMBL12853298 | 0.84 | ADRB2 (0.44) | ADRB2ALDH1A1POLBNPSR1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132178-B1 | JNK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | disclosed |
| US-8975389-B2 | Nucleic acid chemical modifications | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-03-10 | — | — | US | disclosed |