Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15127375 | 1.00 | POLB (0.44) | POLBCYP3A4MAPTKMT2AMEN1 | |
| SCHEMBL13240836 | 0.84 | MAPT (0.55) | POLBMAPTKMT2AMEN1TDP1 | |
| SCHEMBL2486459 | 0.84 | MAPT (0.55) | POLBMAPTKMT2AMEN1TDP1 | |
| Hydrochloric Acid SCHEMBL2486456 | 0.83 | MAPT (0.54) | POLBMAPTKMT2AMEN1TDP1 | |
| SCHEMBL15117446 | 0.80 | CHRM3 (0.54) | KMT2AMEN1TSHR | |
| SCHEMBL12071825 | 0.80 | CHRM3 (0.54) | KMT2AMEN1TSHR | |
| SCHEMBL7610698 | 0.79 | ALDH1A1 (0.41) | CYP3A4MAPTKMT2AMEN1ALDH1A1 | |
| Benzene SCHEMBL29140663 | 0.77 | CYP3A4 (0.59) | CYP3A4MAPTKMT2AMEN1TDP1 | |
| SCHEMBL5098387 | 0.77 | CYP3A4 (0.49) | POLBCYP3A4MAPTKMT2ARAB9A | |
| SCHEMBL16372021 | 0.76 | CYP3A4 (0.61) | CYP3A4KMT2AMEN1TDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585459-B1 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMA SPA (IT) | 2015-01-07 | — | — | EP | disclosed |
| US-8492548-B2 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-23 | — | — | US | disclosed |
| US-8492548-B2 | Alkaloid aminoester derivatives and medicinal compositions thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-23 | — | — | US | disclosed |
| EP-2585459-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011161018-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| WO-2011161018-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311458-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHRM3, CHRM5, CHRM2 | POLB 4016/4885CYP3A4 199/4885MAPT 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.