⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19276036 | 1.00 | — | — | |
| SCHEMBL927400 | 0.76 | — | — | |
| SCHEMBL1565415 | 0.70 | — | — | |
| SCHEMBL124463 | 0.70 | — | — | |
| SCHEMBL31263224 | 0.69 | — | — | |
| SCHEMBL852820 | 0.67 | — | — | |
| SCHEMBL1104578 | 0.53 | ATM (0.42) | — | |
| SCHEMBL406900 | 0.53 | ATM (0.42) | — | |
| SCHEMBL8073612 | 0.52 | — | — | |
| SCHEMBL6399911 | 0.49 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10716770-B2 | Nicotinic receptor non-competitive antagonists | CATALYST BIOSCIENCES, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-20190254991-A1 | Nicotinic Receptor Non-Competitive Antagonists | CATALYST BIOSCIENCES INC (US) | 2019-08-22 | — | — | US | disclosed |
| US-10258582-B2 | Nicotinic receptor non-competitive antagonists | CATALYST BIOSCIENCES, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180271806-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES, INC. | 2018-09-27 | — | — | US | disclosed |
| US-20170240547-A1 | IMIDAZO(4,5-B) PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS | CHANNEL BIOSCIENCES, LLC | 2017-08-24 | — | — | US | disclosed |
| US-9650376-B2 | Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators | KNOPP BIOSCIENCES LLC (US) | 2017-05-16 | — | — | US | disclosed |
| US-20170071878-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES INC (US) | 2017-03-16 | — | — | US | disclosed |
| EP-2576496-B1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | CATALYST BIOSCIENCES INC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9532974-B2 | Nicotinic receptor non-competitive antagonists | TARGACEPT, INC. (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160008323-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT INC (US) | 2016-01-14 | — | — | US | disclosed |
| US-20140315877-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT INC (US) | 2014-10-23 | — | — | US | disclosed |
| US-8809397-B2 | Nicotinic receptor non-competitive antagonists | TARGACEPT, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130203860-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT, INC. | 2013-08-08 | — | — | US | disclosed |
| EP-2576496-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | Targacept, Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011149859-A1 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS | TARGACEPT, INC. (US) | 2011-12-01 | — | — | WO | disclosed |
| EP-2334657-A1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-06-22 | — | — | EP | disclosed |
| US-7858630-B2 | D3 and 5-HT2A receptor modulators | HOFFMANN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100075983-A1 | D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN-LA ROCHE, INC. | 2010-03-25 | — | — | US | disclosed |
| WO-2010031735-A1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |