Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | CPT2 | P23786 | 1/20 | 0.44 |
| ▸ | CPT1A | P50416 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | ATF4 | P18848 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080587 | 0.79 | USP2 (0.66) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL10080588 | 0.78 | USP2 (0.74) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL10064243 | 0.77 | USP2 (0.72) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL12943736 | 0.75 | USP2 (0.69) | USP2MAPK1POLBTDP1BLM | |
| Hydrochloric Acid SCHEMBL17019883 | 0.74 | USP2 (0.68) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL943950 | 0.73 | PKM (0.66) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL17019881 | 0.72 | POLB (0.78) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL15511292 | 0.69 | POLB (0.49) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL15511290 | 0.69 | POLB (0.49) | USP2MAPK1POLBTDP1BLM | |
| SCHEMBL9951224 | 0.69 | USP2 (0.75) | USP2MAPK1POLBTDP1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115086-B2 | Therapeutic compositions and related methods of use | AGIOS PHARMACEUTICALS, INC. (US) | 2015-08-25 | — | — | US | disclosed |