Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17010192 | 0.85 | CRBN (0.40) | SMN1; SMN2GAANPC1RAB9AKDM4E | |
| SCHEMBL6924329 | 0.83 | SPHK1 (0.42) | SPHK1KEAP1NFE2L2BRD4GPR119 | |
| SCHEMBL14350826 | 0.83 | SPHK1 (0.42) | SPHK1KEAP1NFE2L2BRD4GPR119 | |
| SCHEMBL14338696 | 0.83 | SPHK1 (0.42) | SPHK1KEAP1NFE2L2BRD4GPR119 | |
| SCHEMBL16545983 | 0.82 | SPHK1 (0.41) | SPHK1BRD4GPR119STSKDM4E | |
| SCHEMBL17819587 | 0.82 | SPHK1 (0.41) | SPHK1BRD4GPR119STSKDM4E | |
| SCHEMBL3614064 | 0.80 | KEAP1 (0.41) | SMN1; SMN2GAATHRBSPHK1KEAP1 | |
| SCHEMBL3614066 | 0.80 | KEAP1 (0.41) | SMN1; SMN2GAATHRBSPHK1KEAP1 | |
| SCHEMBL1836162 | 0.80 | SPHK1 (0.42) | SPHK1PPARABRD4GPR119STS | |
| SCHEMBL13110173 | 0.80 | KEAP1 (0.41) | SMN1; SMN2GAATHRBSPHK1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104707-B1 | TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS | ALBERT EINSTEIN COLLEGE MEDICINE INC (US) | 2020-07-15 | — | — | EP | disclosed |
| US-10294233-B2 | Treatment of H. pylori infections using MTAN inhibitors | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2019-05-21 | — | — | US | disclosed |
| US-20190016730-A1 | TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-20170166571-A1 | TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170166571-A1 | TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-06-15 | — | — | US | disclosed |
| WO-2015123101-A1 | TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166571-A1 | TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS | MTAP, PNP, UNG | SMN1; SMN2 4567/4885GAA 175/4885THRB 2874/4885 |
| US-10294233-B2 | Treatment of H. pylori infections using MTAN inhibitors | MTAP, PNP, UNG | SMN1; SMN2 4567/4885GAA 175/4885THRB 2874/4885 |
| US-20190016730-A1 | TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS | MTAP, PNP, UNG | SMN1; SMN2 4567/4885GAA 175/4885THRB 2874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.