Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.45 |
| ▸ | STAT6 | P42226 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17021271 | 0.79 | NTRK1 (0.46) | NTRK1STAT6SRCRIPK1KDM4E | |
| SCHEMBL19010318 | 0.74 | NTRK1 (0.46) | NTRK1STAT6SRCRIPK1KDM4E | |
| SCHEMBL17021421 | 0.74 | NTRK1 (0.49) | NTRK1STAT6 | |
| SCHEMBL17021319 | 0.69 | SIRT2 (0.45) | SRCKDM4E | |
| SCHEMBL17021437 | 0.67 | NTRK1 (0.40) | NTRK1STAT6 | |
| SCHEMBL12789100 | 0.65 | TRPM8 (0.64) | RIPK1HTR2CTRPM8 | |
| SCHEMBL1658127 | 0.64 | GRM5 (0.59) | RIPK1HTR2CTRPM8 | |
| SCHEMBL23213621 | 0.64 | HPGD (0.54) | RIPK1MAPTHTR2C | |
| SCHEMBL17021272 | 0.63 | NTRK1 (0.59) | NTRK1STAT6MAPT | |
| SCHEMBL17021409 | 0.63 | STAT6 (0.46) | STAT6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015123453-A1 | PYRIDAZINE COMPOUNDS AS JAK INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |