SCHEMBL1702260

SCHEMBL1702260

c1ccc(CN(c2ccccc2)c2ccc(-c3ccc(N(Cc4ccccc4)c4ccccc4)cc3)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 1/20 0.54
HDAC1 Q13547 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
TAAR1 Q96RJ0 2/20 0.48
KCNA3 P22001 1/20 0.47
TSHR P16473 2/20 0.47
CYP2C19 P33261 1/20 0.45
ALDH1A1 P00352 3/20 0.44
CNR2 P34972 2/20 0.42
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
AOC3 Q16853 1/20 0.41
KCNH2 Q12809 1/20 0.41
PTGES O14684 1/20 0.41
ALOX5 P09917 1/20 0.41
NPC1 O15118 1/20 0.40
GLA P06280 1/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL66561 0.95 TAAR1 (0.54) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL14373647 0.95 TAAR1 (0.54) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL23435088 0.94 NR3C2 (0.50) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL25823394 0.94 NR3C2 (0.50) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL23992546 0.93 TAAR1 (0.57) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL9215743 0.93 TAAR1 (0.56) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL9446230 0.93 NR3C2 (0.59) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL918512 0.91 NR3C2 (0.56) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL28850339 0.90 ESR1 (0.58) NR3C2HDAC1HDAC8HDAC6TAAR1
SCHEMBL22384546 0.90 HDAC1 (0.49) NR3C2HDAC1HDAC8HDAC6TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150037732-A1 METHOD FOR MANUFACTURING PHOTORECEPTOR LAYERS XEROX CORPORATION (US) 2015-02-05 US claimed
US-7267917-B2 Photoreceptor charge transport layer composition XEROX CORPORATION (US) 2007-09-11 US claimed
US-20060063080-A1 Photoreceptor charge transport layer composition XEROX CORPORATION (US) 2006-03-23 US claimed
US-4338222-A Semiconductive organic compositions XEROX CORPORATION (US) 1982-07-06 US claimed
US-4115116-A Imaging member having a polycarbonate-biphenyl diamine charge transport layer XEROX CORPORATION (US) 1978-09-19 US claimed
US-4081274-A Composite layered photoreceptor XEROX CORPORATION (US) 1978-03-28 US claimed
US-20150037732-A1 METHOD FOR MANUFACTURING PHOTORECEPTOR LAYERS XEROX CORPORATION (US) 2015-02-05 US disclosed
EP-1089130-B1 Process for fabricating an electrophotographic imaging member XEROX CORP (US) 2012-04-18 EP disclosed
US-7811728-B2 Imaging members and process for preparing same XEROX CORPORATION (US) 2010-10-12 US disclosed
US-7704656-B2 Photoconductive imaging member XEROX CORPORATION (US) 2010-04-27 US disclosed
US-7648811-B2 Branched polyarylene ethers and processes for the preparation thereof XEROX CORPORATION (US) 2010-01-19 US disclosed
US-7642028-B2 surface layers are a polymeric composition including a resin and a cyclic polymers such as polyethylene terephthalate, acrylic acid-ethylene copolymer, styrene-co-maleic anhydride copolymer; polyhexamethylene adipamide etc. and cyclic poly(bisphenol A carbonate), cyclic poly(bisphenol C carbonate) etc. XEROX CORPORATION (US) 2010-01-05 US disclosed
US-7491989-B2 Positive charging photoreceptor XEROX CORPORATION (US) 2009-02-17 US disclosed
US-4232102-A Imaging system XEROX CORPORATION (US) 1980-11-04 US disclosed
US-4115116-A Imaging member having a polycarbonate-biphenyl diamine charge transport layer XEROX CORPORATION (US) 1978-09-19 US disclosed
US-4115116-A Imaging member having a polycarbonate-biphenyl diamine charge transport layer XEROX CORPORATION (US) 1978-09-19 US disclosed
US-4081274-A Composite layered photoreceptor XEROX CORPORATION (US) 1978-03-28 US disclosed
US-4078925-A Composite layered photoreceptor XEROX CORPORATION (US) 1978-03-14 US disclosed
US-4047948-A Composite layered imaging member for electrophotography XEROX CORPORATION (US) 1977-09-13 US disclosed
US-4047949-A Composite layered imaging member for electrophotography XEROX CORPORATION (US) 1977-09-13 US disclosed