Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 8/20 | 0.59 |
| ▸ | JAK3 | P52333 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8516627 | 0.94 | CYP1A2 (0.60) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL17022955 | 0.91 | CYP1A2 (0.62) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL17022939 | 0.90 | CYP1A2 (0.61) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL2996894 | 0.86 | ABL1 (0.47) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL8513543 | 0.84 | CYP1A2 (0.61) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL4437883 | 0.83 | CDK1 (0.53) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL2988143 | 0.81 | ABL1 (0.44) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL17022943 | 0.81 | CYP1A2 (0.53) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL17022948 | 0.80 | CYP1A2 (0.61) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL17022950 | 0.78 | CYP1A2 (0.63) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137164-B1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-08-26 | — | — | EP | claimed |