SCHEMBL17022950

SCHEMBL17022950

CCN(CC)Cc1cccc(-c2cc(Nc3ccc(NS(C)(=O)=O)cc3)ncn2)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 7/20 0.63
CYP3A4 P08684 7/20 0.63
CYP2C19 P33261 5/20 0.63
CLK4 Q9HAZ1 4/20 0.63
CYP2C9 P11712 4/20 0.63
CYP2D6 P10635 3/20 0.63
USP2 O75604 2/20 0.63
TSHR P16473 2/20 0.63
HSD17B10 Q99714 5/20 0.55
ALDH1A1 P00352 4/20 0.55
BACE1 P56817 7/20 0.53
MAPK1 P28482 3/20 0.52
CCNT1 O60563 3/20 0.52
CDK9 P50750 3/20 0.52
KDM4E B2RXH2 2/20 0.52
HIF1A Q16665 2/20 0.52
HPGD P15428 1/20 0.52
ABL1 P00519 2/20 0.52
BCR P11274 2/20 0.52
TP53 P04637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8514815 0.93 CYP1A2 (0.65) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL2988024 0.86 CCNT1 (0.49) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8515874 0.82 CYP1A2 (0.67) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8514812 0.82 CCNT1 (0.59) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL17022948 0.81 CYP1A2 (0.61) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL17022939 0.81 CYP1A2 (0.61) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL2993794 0.80 CYP1A2 (0.42) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL17022955 0.79 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8515866 0.78 CYP3A4 (0.70) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL17022947 0.78 CYP1A2 (0.60) CYP1A2CYP3A4CYP2C19CLK4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2137164-B1 INHIBITORS OF PROTEIN KINASES ASTRAZENECA AB (SE) 2015-08-26 EP claimed