Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 16/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023063 | 0.90 | FGFR3 (0.64) | FGFR3CHEK1 | |
| SCHEMBL1127101 | 0.89 | FGFR3 (0.70) | FGFR3F10 | |
| SCHEMBL17023152 | 0.86 | FGFR3 (0.62) | FGFR3 | |
| SCHEMBL17023151 | 0.83 | FGFR3 (0.68) | FGFR3F10 | |
| SCHEMBL17023177 | 0.82 | FGFR3 (0.81) | FGFR3 | |
| SCHEMBL17023078 | 0.82 | FGFR3 (0.81) | FGFR3CHEK1 | |
| SCHEMBL3317617 | 0.81 | FGFR3 (0.50) | FGFR3CHEK1BCHEACHE | |
| SCHEMBL17023050 | 0.79 | FGFR3 (0.68) | FGFR3 | |
| SCHEMBL3316242 | 0.79 | FGFR3 (0.51) | FGFR3BCHEACHE | |
| SCHEMBL1126353 | 0.78 | FGFR3 (0.81) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |