SCHEMBL17023102

SCHEMBL17023102

COc1cc(OC)c(Cl)c(-c2ccc(OC(=O)Nc3ccccn3)c3ncc(N(C)CCN(C)C)nc23)c1Cl

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 19/20 0.79
FGFR1 P11362 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1126358 0.88 FGFR3 (1.00) FGFR3
SCHEMBL17023145 0.87 FGFR3 (0.62) FGFR3
SCHEMBL17023058 0.86 FGFR3 (0.79) FGFR3FGFR1
SCHEMBL17023055 0.83 FGFR3 (0.57) FGFR3
SCHEMBL17023099 0.80 FGFR3 (0.79) FGFR3
SCHEMBL1126124 0.78 FGFR3 (0.72) FGFR3FGFR1
SCHEMBL17023117 0.78 FGFR3 (0.63) FGFR3FGFR1
SCHEMBL4331503 0.77 FGFR3 (0.76) FGFR3
SCHEMBL17023151 0.77 FGFR3 (0.68) FGFR3
SCHEMBL1126555 0.77 FGFR3 (0.76) FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2282995-B1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2015-08-26 EP claimed