SCHEMBL17023105

SCHEMBL17023105

COc1cc(OC)c(Cl)c(-c2ccc(OC(=O)Nc3ccc(CN4CCN(C(C)C)CC4)cc3)c3nccnc23)c1Cl

nearest known ligand 0.79

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 20/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17023067 0.91 FGFR3 (0.65) FGFR3
SCHEMBL12678228 0.89 FGFR3 (1.00) FGFR3
SCHEMBL17023056 0.88 FGFR3 (0.79) FGFR3
SCHEMBL17023101 0.85 FGFR3 (0.64) FGFR3
SCHEMBL17023023 0.84 FGFR3 (0.63) FGFR3
SCHEMBL17023062 0.82 FGFR3 (0.66) FGFR3
SCHEMBL17023138 0.81 FGFR3 (0.67) FGFR3
SCHEMBL17023047 0.81 FGFR3 (0.70) FGFR3
SCHEMBL17023100 0.81 FGFR3 (0.80) FGFR3
SCHEMBL17023115 0.81 FGFR3 (0.67) FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2282995-B1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2015-08-26 EP claimed