Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 14/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023066 | 0.91 | FGFR3 (0.78) | FGFR3NPC1RAB9AMAPTFGFR1 | |
| SCHEMBL17023062 | 0.91 | FGFR3 (0.66) | FGFR3NPC1POLBRAB9AMAPT | |
| SCHEMBL17023056 | 0.91 | FGFR3 (0.79) | FGFR3NPC1RAB9AFGFR1 | |
| SCHEMBL17023048 | 0.90 | FGFR3 (0.64) | FGFR3FGFR1 | |
| SCHEMBL1126459 | 0.88 | FGFR3 (0.84) | FGFR3NPC1RAB9AMAPTTSHR | |
| SCHEMBL17023040 | 0.84 | FGFR3 (0.55) | FGFR3POLB | |
| SCHEMBL17023138 | 0.83 | FGFR3 (0.67) | FGFR3 | |
| SCHEMBL17023181 | 0.82 | FGFR3 (0.59) | FGFR3POLBFGFR1KDR | |
| SCHEMBL17023176 | 0.81 | FGFR3 (0.80) | FGFR3FGFR1KDR | |
| SCHEMBL17023042 | 0.81 | FGFR3 (0.61) | FGFR3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |