Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADM2 | Q7Z4H4 | 8/20 | 0.50 |
| ▸ | CALCRL | Q16602 | 12/20 | 0.48 |
| ▸ | CALCB | P10092 | 7/20 | 0.47 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.46 |
| ▸ | CALCA | P06881 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036260 | 0.88 | ADM2 (0.48) | ADM2CALCRLCALCB | |
| Hydrochloric Acid SCHEMBL3045318 | 0.87 | ADM2 (0.47) | ADM2CALCRLCALCB | |
| SCHEMBL549078 | 0.85 | ADM2 (0.52) | ADM2CALCRLCALCBRAMP1CALCA | |
| SCHEMBL3048932 | 0.81 | ADM2 (0.47) | ADM2CALCRLCALCB | |
| SCHEMBL550276 | 0.80 | ADM2 (0.51) | ADM2CALCRLCALCBRAMP1CALCA | |
| SCHEMBL3040463 | 0.78 | ADM2 (0.48) | ADM2CALCRLCALCB | |
| SCHEMBL31039432 | 0.77 | ADM2 (0.61) | ADM2CALCRLCALCB | |
| SCHEMBL10246286 | 0.77 | ADM2 (0.61) | ADM2CALCRLCALCB | |
| SCHEMBL3036259 | 0.77 | ADM2 (0.50) | ADM2CALCRLCALCB | |
| SCHEMBL12414790 | 0.77 | ADM2 (0.60) | ADM2CALCRLCALCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225227-B1 | 1',3'-Dihydrospiro[imidazolidin-4,2'-inden]-2,5-diones and 1,3-dihydrospiro[inden-2,3']-pyrroles as CGRP antagonists | BOEHRINGER INGELHEIM INT (DE) | 2015-08-26 | — | — | EP | disclosed |