Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15712293 | 0.91 | HTR7 (0.62) | HTR7CYP1A2CDC7MAPTCNR1 | |
| SCHEMBL2479169 | 0.89 | HTR7 (0.47) | HTR7CYP1A2MAPTCNR1ACHE | |
| SCHEMBL1121948 | 0.86 | HTR7 (0.56) | HTR7CYP1A2CDC7MAPTAR | |
| SCHEMBL7798236 | 0.86 | HTR7 (0.56) | HTR7CDC7MAPTIRAK4AR | |
| SCHEMBL7806961 | 0.86 | HTR7 (0.56) | HTR7CYP1A2CDC7MAPTAR | |
| SCHEMBL12857291 | 0.86 | HTR7 (0.56) | HTR7CYP1A2CDC7MAPT | |
| SCHEMBL1121943 | 0.85 | HTR7 (0.54) | HTR7CYP1A2MAPTIRAK4 | |
| SCHEMBL3312100 | 0.85 | HTR7 (0.57) | HTR7CYP1A2CDC7MAPTMTNR1A | |
| SCHEMBL1121884 | 0.85 | HTR7 (0.56) | HTR7CYP1A2CDC7MAPTMTNR1A | |
| SCHEMBL8265180 | 0.85 | HTR7 (0.56) | HTR7CDC7MAPTMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104788328-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2015-07-22 | — | — | CN | claimed |
| CN-103641765-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2014-03-19 | — | — | CN | claimed |
| EP-2007756-B1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2015-08-26 | — | — | EP | disclosed |
| CN-104788328-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2015-07-22 | — | — | CN | disclosed |
| CN-101891680-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-29 | — | — | CN | disclosed |
| CN-103641765-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2014-03-19 | — | — | CN | disclosed |
| CN-101821266-B | Modulators of cystic fibrosis transmembrane channel regulators | VERTEX PHARMA | 2014-03-12 | — | — | CN | disclosed |
| CN-101935301-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2013-10-16 | — | — | CN | disclosed |
| CN-102652128-A | 4-Oxo-1H-quinoline-3-carboxamides as modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2012-08-29 | — | — | CN | disclosed |
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101821266-A | Modulators of cystic fibrosis transmembrane channel regulators | VERTEX PHARMA | 2010-09-01 | — | — | CN | disclosed |
| CN-101687883-A | modulators of cystic fibrosis transmembrane conductance regulator | VERTEX PHARMA | 2010-03-31 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |