Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluorescein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 10/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | HPGD | P15428 | 2/20 | 0.75 |
| ▸ | RECQL | P46063 | 2/20 | 0.75 |
| ▸ | BLM | P54132 | 2/20 | 0.75 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.75 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein SCHEMBL28075803 | 0.95 | FTO (0.82) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL28819738 | 0.94 | FTO (0.77) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL28987181 | 0.94 | FTO (0.81) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL5664541 | 0.94 | FTO (0.85) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL27822133 | 0.94 | FTO (0.85) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL16545 | 0.94 | FTO (0.85) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL5960075 | 0.94 | FTO (0.69) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL5440615 | 0.93 | FTO (0.82) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL2361033 | 0.93 | FTO (0.87) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL20239317 | 0.93 | FTO (0.87) | FTOMAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9151748-B2 | Signal amplification microspheres, their use in one-step and multi-step analytical amplification procedures and methods for their production | SUPERNOVA DIAGNOSTICS, INC. (US) | 2015-10-06 | — | — | US | claimed |
| US-8980572-B2 | Methods of signal generation and signal localization for improvement of signal readability in solid phase based bioassays | SUPERNOVA DIAGNOSTICS, INC. (US) | 2015-03-17 | — | — | US | claimed |
| EP-2440926-B1 | Methods of production of signal amplification microspheres | SUPERNOVA DIAGNOSTICS INC (US) | 2014-12-10 | — | — | EP | claimed |
| EP-2440929-B1 | Methods of signal generation and signal localization for improvement of signal readability in solid phase based bioassays | SUPERNOVA DIAGNOSTICS INC (US) | 2014-07-30 | — | — | EP | claimed |
| US-20120171747-A1 | SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION | SUPERNOVA DIAGNOSTICS, INC. (US) | 2012-07-05 | — | — | US | claimed |
| US-20120156693-A1 | METHODS OF SIGNAL GENERATION AND SIGNAL LOCALIZATION FOR IMPROVEMENT OF SIGNAL READABILITY IN SOLID PHASE BASED BIOASSAYS | SUPERNOVA DIAGNOSTICS, INC. (US) | 2012-06-21 | — | — | US | claimed |
| EP-2440926-A1 | SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION | Supernova Diagnostics, Inc. (US) | 2012-04-18 | — | — | EP | claimed |
| WO-2010142963-A1 | METHODS OF SIGNAL GENERATION AND SIGNAL LOCALIZATION FOR IMPROVEMENT OF SIGNAL READABILITY IN SOLID PHASE BASED BIOASSAYS | DNA SUPERNOVA LTD (CN) | 2010-12-16 | — | — | WO | claimed |
| WO-2010142960-A1 | SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION | DNA SUPERNOVA LTD (CN) | 2010-12-16 | — | — | WO | claimed |
| US-20160047802-A1 | SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION | SUPERNOVA DIAGNOSTICS, INC. (US) | 2016-02-18 | — | — | US | disclosed |
| US-9151748-B2 | Signal amplification microspheres, their use in one-step and multi-step analytical amplification procedures and methods for their production | SUPERNOVA DIAGNOSTICS, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-8980572-B2 | Methods of signal generation and signal localization for improvement of signal readability in solid phase based bioassays | SUPERNOVA DIAGNOSTICS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| EP-2440926-B1 | Methods of production of signal amplification microspheres | SUPERNOVA DIAGNOSTICS INC (US) | 2014-12-10 | — | — | EP | disclosed |
| EP-2440929-B1 | Methods of signal generation and signal localization for improvement of signal readability in solid phase based bioassays | SUPERNOVA DIAGNOSTICS INC (US) | 2014-07-30 | — | — | EP | disclosed |
| US-20120171747-A1 | SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION | SUPERNOVA DIAGNOSTICS, INC. (US) | 2012-07-05 | — | — | US | disclosed |
| US-20120156693-A1 | METHODS OF SIGNAL GENERATION AND SIGNAL LOCALIZATION FOR IMPROVEMENT OF SIGNAL READABILITY IN SOLID PHASE BASED BIOASSAYS | SUPERNOVA DIAGNOSTICS, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| EP-2440929-A1 | METHODS OF SIGNAL GENERATION AND SIGNAL LOCALIZATION FOR IMPROVEMENT OF SIGNAL READABILITY IN SOLID PHASE BASED BIOASSAYS | Supernova Diagnostics, Inc. (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142963-A1 | METHODS OF SIGNAL GENERATION AND SIGNAL LOCALIZATION FOR IMPROVEMENT OF SIGNAL READABILITY IN SOLID PHASE BASED BIOASSAYS | DNA SUPERNOVA LTD (CN) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010142960-A1 | SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION | DNA SUPERNOVA LTD (CN) | 2010-12-16 | — | — | WO | disclosed |