Sugi Predict

Sugi Predict / Compounds / SCHEMBL17023905

SCHEMBL17023905

SCHEMBL17023905

c1ccc(-c2nc(-c3cnc(-c4nc(-c5ccccn5)n5ccccc45)cn3)c3ccccn23)nc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 1/20 0.43
▸ BRD2 P25440 1/20 0.43
▸ BRD3 Q15059 1/20 0.43
▸ BAZ2B Q9UIF8 1/20 0.43
▸ BAZ2A Q9UIF9 1/20 0.43
▸ PTGS2 P35354 1/20 0.41
▸ GABRA1 P14867 1/20 0.41
▸ GABRG2 P18507 1/20 0.41
▸ GABRB3 P28472 1/20 0.41
▸ GABRA3 P34903 1/20 0.41
▸ GAA P10253 7/20 0.40
▸ KDM4E B2RXH2 5/20 0.40
▸ HTT P42858 4/20 0.40
▸ SMN1; SMN2 Q16637 4/20 0.40
▸ TDP1 Q9NUW8 4/20 0.40
▸ MAPT P10636 4/20 0.40
▸ LMNA P02545 4/20 0.40
▸ L3MBTL1 Q9Y468 4/20 0.40
▸ NPSR1 Q6W5P4 3/20 0.40
▸ MAPK1 P28482 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17023904 0.86 KDM4E (0.47) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL17023894 0.86 GAA (0.50) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL17023902 0.86 GAA (0.40) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL17023877 0.85 GAA (0.46) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL25787087 0.85 KMT2A (0.56) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL17023881 0.82 GAA (0.47) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL17023872 0.82 BRD4 (0.41) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL17023897 0.82 KDM4E (0.50) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL24770380 0.82 BRD4 (0.46) BRD4BRD2BRD3BAZ2BBAZ2A
SCHEMBL24097052 0.82 GAA (0.49) BRD4BRD2BRD3BAZ2BBAZ2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10847726-B2 Imidizo derivatives THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 2020-11-24 — — US disclosed
US-10847726-B2 Imidizo derivatives THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 2020-11-24 — — US disclosed
US-20190131538-A1 IMIDIZO DERIVATIVES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY 2019-05-02 — — US disclosed
US-20190131538-A1 IMIDIZO DERIVATIVES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY 2019-05-02 — — US disclosed
US-20150243896-A1 IMIDAZO DERIVATIVES ARMY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE 2015-08-27 — — US disclosed
US-20150243896-A1 IMIDAZO DERIVATIVES ARMY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE 2015-08-27 — — US disclosed
US-20150243896-A1 IMIDAZO DERIVATIVES ARMY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE 2015-08-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190131538-A1 IMIDIZO DERIVATIVES IKZF1, IKZF3, IKZF2 BRD4 96/4885BRD2 128/4885BRD3 90/4885
US-10847726-B2 Imidizo derivatives IKZF1, IKZF3, IKZF2 BRD4 96/4885BRD2 128/4885BRD3 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.