Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367879 | 0.88 | NCF1 (0.60) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL13946389 | 0.82 | NCF1 (0.65) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E | |
| Hydrochloric Acid SCHEMBL4192881 | 0.81 | NCF1 (0.63) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL11196105 | 0.81 | NCF1 (0.83) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL13883597 | 0.80 | SMN1; SMN2 (0.58) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL17754101 | 0.79 | SMN1; SMN2 (0.63) | NCF1SMN1; SMN2ALDH1A1HTTNOS1 | |
| SCHEMBL30577399 | 0.79 | SMN1; SMN2 (0.63) | NCF1SMN1; SMN2ALDH1A1HTTNOS1 | |
| SCHEMBL1037060 | 0.79 | NCF1 (0.65) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL14368311 | 0.78 | NCF1 (0.56) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL27705944 | 0.78 | SMN1; SMN2 (0.53) | NCF1SMN1; SMN2ALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CNKSR1, MOK, MAPK1 | NCF1 1870/4885SMN1; SMN2 4215/4885ALDH1A1 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.