Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | NAAA | Q02083 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078107 | 0.80 | HTT (0.86) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL9260536 | 0.80 | HTT (0.86) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL5362359 | 0.80 | HTT (0.86) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL11089468 | 0.80 | HTT (0.86) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL4600712 | 0.79 | NAAA (0.65) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL2359602 | 0.79 | NAAA (0.61) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL21210751 | 0.78 | NAAA (0.59) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL7475869 | 0.77 | HTT (0.55) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL19210845 | 0.77 | TSHR (1.00) | HTTTSHRNAAAHPGDHCRTR1 | |
| SCHEMBL23169262 | 0.77 | TSHR (0.68) | HTTTSHRNAAAHPGDHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107898-A1 | 1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015124932-A1 | 1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS | TAKEDA CAMBRIDGE LIMITED (GB) | 2015-08-27 | — | — | WO | disclosed |