Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | VEGFA | P15692 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17005933 | 0.89 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1POLBTDP1 | |
| SCHEMBL17005893 | 0.88 | ALDH1A1 (0.60) | MEN1KMT2AALDH1A1POLBTDP1 | |
| SCHEMBL17005898 | 0.88 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1POLBTDP1 | |
| SCHEMBL28913770 | 0.85 | EGLN1 (0.65) | MEN1KMT2AALDH1A1POLBTDP1 | |
| SCHEMBL17005925 | 0.81 | NPC1 (0.58) | MEN1KMT2AALDH1A1POLBEGLN1 | |
| SCHEMBL17005923 | 0.80 | NPC1 (0.52) | MEN1KMT2AALDH1A1POLBEGLN1 | |
| SCHEMBL17005913 | 0.80 | NPC1 (0.54) | MEN1KMT2AALDH1A1EGLN1KDM4E | |
| SCHEMBL28576610 | 0.77 | VEGFA (0.65) | MEN1KMT2AALDH1A1EGLN1KDM4E | |
| SCHEMBL12649400 | 0.77 | VEGFA (0.69) | MEN1KMT2AALDH1A1EGLN1KDM4E | |
| SCHEMBL1773790 | 0.76 | VEGFA (0.71) | MEN1KMT2AALDH1A1TDP1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107542-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | Aerpio Therapeutics, Inc. (US) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015126860-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | AERPIO THERAPEUTICS, INC. (US) | 2015-08-27 | — | — | WO | disclosed |