Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.53 |
| ▸ | ABL1 | P00519 | 7/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | BLK | P51451 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 5/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363647 | 0.88 | KDR (0.68) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL13372713 | 0.81 | KDR (0.52) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL27636380 | 0.79 | AURKA (0.49) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL3392985 | 0.78 | KDR (0.72) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL1703611 | 0.78 | KDR (0.78) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL27657548 | 0.76 | KDR (0.48) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL27636446 | 0.76 | KDR (0.64) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL27657352 | 0.76 | KDR (0.66) | KDRABL1LCKCSF1RFLT1 | |
| SCHEMBL4739859 | 0.76 | KDR (0.63) | KDRABL1FYNLCKCSF1R | |
| SCHEMBL4740070 | 0.75 | KDR (0.62) | KDRABL1FYNLCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807424-B1 | NOVEL KINASE INHIBITORS | ABBOTT LAB (US) | 2012-04-18 | — | — | EP | claimed |