Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17029024 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL17029026 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL17029055 | 0.84 | CYP3A4 (0.36) | SMN1; SMN2TP53 | |
| SCHEMBL17029008 | 0.83 | KMO (0.43) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL18364985 | 0.79 | CNR2 (0.38) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL17039242 | 0.79 | CNR2 (0.38) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL20344785 | 0.79 | CNR2 (0.38) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL17029010 | 0.78 | NPC1 (0.41) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL17029013 | 0.77 | F2RL3 (0.40) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 | |
| SCHEMBL17039247 | 0.76 | KDM4E (0.40) | SMN1; SMN2TP53MAPK13DYRK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107913-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE (NO.5) LIMITED (GB) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015126765-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-08-27 | — | — | WO | disclosed |