Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 3/20 | 0.39 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17029493 | 0.90 | SLC6A4 (0.41) | ALOX15KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL730011 | 0.85 | KCNH2 (0.39) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| Hydrochloric Acid SCHEMBL729973 | 0.83 | MAOB (0.39) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL17546370 | 0.82 | KDM4A (0.40) | KDM4AKDM4BKDM4CALOX15KDM1A | |
| SCHEMBL728236 | 0.76 | SLC6A4 (0.44) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17546372 | 0.73 | SLC6A4 (0.38) | KDM4AKDM4BKDM4CKDM1ASLC6A2 | |
| SCHEMBL733557 | 0.73 | KDM4A (0.45) | KDM4AKDM4BKDM4CALOX15SLC6A2 | |
| SCHEMBL17552306 | 0.73 | MAOB (0.44) | KDM4AKDM4BKDM4CMAOBMAOA | |
| SCHEMBL14038495 | 0.72 | KDM4A (0.46) | KDM4AKDM4BKDM4CSLC6A2SLC6A4 | |
| SCHEMBL14216756 | 0.72 | KDM1A (0.35) | KDM1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | disclosed |