Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | KDM4A | O75164 | 3/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17546370 | 0.91 | KDM4A (0.40) | SLC6A4SLC6A2SLC6A3OPRM1OPRL1 | |
| SCHEMBL17029493 | 0.83 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL17029494 | 0.73 | KDM4A (0.39) | SLC6A4SLC6A2SLC6A3KDM4AKDM4B | |
| SCHEMBL17552337 | 0.71 | MAOB (0.41) | SLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL23374675 | 0.65 | GRIA4 (0.53) | KDM1A | |
| SCHEMBL12354245 | 0.65 | GRIA4 (0.49) | KDM1A | |
| SCHEMBL5019411 | 0.65 | GRIA4 (0.49) | KDM1A | |
| SCHEMBL5019407 | 0.65 | GRIA4 (0.53) | KDM1A | |
| SCHEMBL17546371 | 0.65 | DRD2 (0.42) | SLC6A4SLC6A2SLC6A3OPRM1OPRL1 | |
| SCHEMBL17552306 | 0.64 | MAOB (0.44) | OPRL1KDM4AKDM4BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |