Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19741606 | 0.73 | KMT2A (0.48) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL17030267 | 0.73 | POLB (0.44) | POLBTSHRMEN1MAPTKMT2A | |
| SCHEMBL19741607 | 0.70 | GAA (0.48) | POLBTSHRMEN1MAPTKMT2A | |
| SCHEMBL14225120 | 0.65 | POLB (0.89) | POLBTSHRMAPTALDH1A1MAPK1 | |
| SCHEMBL19355164 | 0.65 | POLB (0.89) | POLBTSHRMAPTALDH1A1MAPK1 | |
| SCHEMBL8067771 | 0.65 | POLB (0.82) | POLBTSHRMAPTALDH1A1MAPK1 | |
| SCHEMBL8067775 | 0.65 | POLB (0.82) | POLBTSHRMAPTALDH1A1MAPK1 | |
| SCHEMBL14025828 | 0.65 | GAA (0.46) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL694516 | 0.65 | GAA (0.46) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL14025826 | 0.65 | GAA (0.46) | POLBMEN1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015124663-A1 | ENANTIOPURE TETRASUBSTITUTED PYRROLIDINES AS SCAFFOLDS FOR PROTEASOME INHIBITORS AND MEDICINAL APPLICATIONS THEREOF | IKERCHEM, S.L. (ES) | 2015-08-27 | — | — | WO | disclosed |
| EP-2910557-A1 | Enantiopure tetrasubstituted pyrrolidines as scaffolds for proteasome inhibitors and medicinal applications thereof | Ikerchem, S.L. (ES) | 2015-08-26 | — | — | EP | disclosed |