Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 6/20 | 0.42 |
| ▸ | WNT3A | P56704 | 6/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14403556 | 0.96 | CTNNB1 (0.46) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL30940052 | 0.89 | PRKCI (0.47) | PRKCIDYRK1ADYRK1BPOLBRAB9A | |
| SCHEMBL3490885 | 0.89 | PRKCI (0.47) | PRKCIDYRK1ADYRK1BPOLBRAB9A | |
| SCHEMBL12447477 | 0.82 | CTNNB1 (0.46) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL13262203 | 0.82 | KDM4E (0.43) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL28841018 | 0.82 | KCNH2 (0.46) | — | |
| SCHEMBL1174021 | 0.79 | CYP2D6 (0.47) | RAB9AKDM1AMAOAMAOBNPC1 | |
| SCHEMBL25478128 | 0.79 | CTNNB1 (0.46) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL6115283 | 0.79 | CTNNB1 (0.47) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL18000486 | 0.79 | CTNNB1 (0.46) | CTNNB1WNT3APRKCICLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007756-B1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2015-08-26 | — | — | EP | disclosed |