Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 6/20 | 0.46 |
| ▸ | WNT3A | P56704 | 6/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366473 | 0.96 | CTNNB1 (0.49) | CTNNB1WNT3APRKCIPOLBRAB9A | |
| SCHEMBL317341 | 0.89 | PRKCI (0.51) | PRKCIPOLBRAB9ANPC1CYP4F2 | |
| SCHEMBL30922323 | 0.89 | PRKCI (0.51) | PRKCIPOLBRAB9ANPC1CYP4F2 | |
| SCHEMBL15853567 | 0.86 | DYRK1A (0.46) | CTNNB1WNT3APOLBRAB9ANPC1 | |
| SCHEMBL2140286 | 0.83 | CTNNB1 (0.47) | CTNNB1WNT3APRKCIPOLBRAB9A | |
| SCHEMBL17030554 | 0.82 | CTNNB1 (0.42) | CTNNB1WNT3APRKCIPOLBRAB9A | |
| SCHEMBL13262203 | 0.82 | KDM4E (0.43) | CTNNB1WNT3APRKCIPOLBRAB9A | |
| SCHEMBL28841074 | 0.82 | KCNH2 (0.46) | CTNNB1WNT3A | |
| SCHEMBL16472555 | 0.81 | PDCD1 (0.49) | RAB9APDCD1CD274ALDH1A1KDM1A | |
| SCHEMBL15853566 | 0.81 | PDCD1 (0.49) | RAB9APDCD1CD274ALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776359-B1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2011-08-24 | — | — | EP | disclosed |