⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13282251 | 1.00 | — | — | |
| SCHEMBL20402373 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL5626475 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL5625749 | 0.97 | — | — | |
| SCHEMBL12640459 | 0.94 | — | — | |
| SCHEMBL1703756 | 0.94 | — | — | |
| SCHEMBL17771870 | 0.94 | — | — | |
| SCHEMBL9112886 | 0.94 | — | — | |
| SCHEMBL20877636 | 0.92 | THRB (0.45) | — | |
| SCHEMBL1703212 | 0.92 | THRB (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015179743-A1 | LIBRARY AND SCREENING APPROACH FOR IMPROVED CELL PENETRATING PEPTIDES | GENZYME CORPORATION (US) | 2015-11-26 | — | — | WO | claimed |
| US-20110195898-A1 | TREATMENT OF ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT USING GNRH-I ANALOGS AND ONE OR MORE OF ACETYLCHOLINESTERASE INHIBITORS AND NMDA RECEPTOR ANTAGONISTS | VOYAGER PHARMACEUTICAL CORPORATION (US) | 2011-08-11 | — | — | US | claimed |
| US-20080171736-A1 | Treatment of Alzheimer's Disease and Mild Cognitive impairment using GnRH-I analogs and one or more of acetylcholinesterase inhibitors and NMDA receptor antagonists | VOYAGER PHARMACEUTICAL CORPORATION | 2008-07-17 | — | — | US | claimed |
| US-5538997-A | HIV PROTEINASE INHIBITORS | SANDOZ LTD. (CH) | 1996-07-23 | — | — | US | claimed |
| EP-0615969-A1 | 2,4-Diamino-3-hydroxycarboxylic acid derivatives | SANDOZ LTD. (CH) | 1994-09-21 | — | — | EP | claimed |
| EP-0417454-A2 | Reduced size LHRH analogs | ABBOTT LABORATORIES (US) | 1991-03-20 | — | — | EP | claimed |
| EP-0413209-A1 | LHRH analogs | TAP Pharmaceuticals Inc. (US) | 1991-02-20 | — | — | EP | claimed |
| US-11801311-B2 | Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides | GENZYME CORPORATION (US) | 2023-10-31 | — | — | US | disclosed |
| EP-3795687-A1 | INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES | Genzyme Corporation (US) | 2021-03-24 | — | — | EP | disclosed |
| US-20210030893-A1 | INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES | GENZYME CORPORATION | 2021-02-04 | — | — | US | disclosed |
| EP-3146050-B1 | INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES | GENZYME CORP (US) | 2020-08-12 | — | — | EP | disclosed |
| US-10682423-B2 | Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides | GENZYME CORPORATION (US) | 2020-06-16 | — | — | US | disclosed |
| CN-106459975-B | Multiple oligonucleotide moieties on peptide carriers | 建新公司 | 2020-03-27 | — | — | CN | disclosed |
| US-5538997-A | HIV PROTEINASE INHIBITORS | SANDOZ LTD. (CH) | 1996-07-23 | — | — | US | disclosed |
| EP-0615969-A1 | 2,4-Diamino-3-hydroxycarboxylic acid derivatives | SANDOZ LTD. (CH) | 1994-09-21 | — | — | EP | disclosed |
| US-5300492-A | Suppressing levels of sex hormones in male or female mammals | TAP PHARMACEUTICALS (US) | 1994-04-05 | — | — | US | disclosed |
| US-5140009-A | Stable against proteolytic enzymes; anticarcinogenic agents; urogenital disorders | TAP PHARMACEUTICALS, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| US-5110904-A | Luteinizing hormone releasing hormone; suppression of sex hormones | ABBOTT LABORATORIES (US) | 1992-05-05 | — | — | US | disclosed |
| EP-0417454-A2 | Reduced size LHRH analogs | ABBOTT LABORATORIES (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0413209-A1 | LHRH analogs | TAP Pharmaceuticals Inc. (US) | 1991-02-20 | — | — | EP | disclosed |