SCHEMBL17033465

SCHEMBL17033465

c1ccc(-c2cncc(-n3c4ccccc4c4cc5c(cc43)cc3c4ccccc4c4ccccc4n53)c2)cc1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
KDM4E B2RXH2 2/20 0.37
ATM Q13315 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
RAC2 P15153 1/20 0.32
RAC3 P60763 1/20 0.32
CDC42 P60953 1/20 0.32
RAC1 P63000 1/20 0.32
NPY5R Q15761 2/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
CYP11B1 P15538 2/20 0.31
KMT2A Q03164 1/20 0.31
CYP11B2 P19099 1/20 0.31
LRRK2 Q5S007 1/20 0.31
MKNK1 Q9BUB5 1/20 0.30
MKNK2 Q9HBH9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17033610 0.96 CHRNB4 (0.39) CHRNB4CHRNA3KDM4EATML3MBTL1
SCHEMBL16066213 0.93 CHRNB4 (0.40) CHRNB4CHRNA3KDM4EATML3MBTL1
SCHEMBL16067233 0.91 CHRNB4 (0.38) CHRNB4CHRNA3KDM4EATML3MBTL1
SCHEMBL16066398 0.91 CHRNB4 (0.38) CHRNB4CHRNA3KDM4EATML3MBTL1
SCHEMBL16067016 0.89 CHRNB4 (0.39) CHRNB4CHRNA3KDM4EATML3MBTL1
SCHEMBL17033462 0.86 KDM4E (0.42) KDM4EATML3MBTL1RAC2RAC3
SCHEMBL19342649 0.86 L3MBTL1 (0.53) CHRNB4CHRNA3KDM4EATML3MBTL1
SCHEMBL17033788 0.85 KDM4E (0.37) CHRNB4CHRNA3KDM4EATML3MBTL1
SCHEMBL17033469 0.85 ATM (0.45) KDM4EATML3MBTL1NPY5RTSHR
SCHEMBL19342707 0.84 ATM (0.43) CHRNB4CHRNA3KDM4EATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015125986-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 주식회사 두산 2015-08-27 WO disclosed