Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 1.00 |
| ▸ | BTK | Q06187 | 10/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.66 |
| ▸ | FER | P16591 | 5/20 | 0.66 |
| ▸ | BLK | P51451 | 5/20 | 0.66 |
| ▸ | STK3 | Q13188 | 5/20 | 0.66 |
| ▸ | RET | P07949 | 5/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.66 |
| ▸ | AURKA | O14965 | 5/20 | 0.66 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.66 |
| ▸ | FYN | P06241 | 5/20 | 0.66 |
| ▸ | MET | P08581 | 5/20 | 0.66 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.66 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.66 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.66 |
| ▸ | FLT1 | P17948 | 5/20 | 0.66 |
| ▸ | KIT | P10721 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29549573 | 1.00 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| SCHEMBL18579380 | 0.87 | KDR (0.76) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL3381224 | 0.79 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL29373142 | 0.79 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL29496449 | 0.79 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| SCHEMBL5472344 | 0.79 | KDR (0.65) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL30406133 | 0.79 | KDR (0.98) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL11898929 | 0.79 | KDR (0.98) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL11900182 | 0.79 | KDR (0.94) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL11899788 | 0.79 | KDR (0.94) | KDRBTKFGFR1AURKBFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112351-B1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-03-30 | — | — | EP | disclosed |
| US-9914707-B2 | Naphthylamide compound, preparation method and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2018-03-13 | — | — | US | disclosed |
| US-20170066723-A1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-03-09 | — | — | US | disclosed |
| EP-3112351-A1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015124101-A1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | 中国科学院上海药物研究所 | 2015-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066723-A1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | KDR, FLT1, FLT4 | KDR 1/4885BTK 458/4885FGFR1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.