Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 1.00 |
| ▸ | BTK | Q06187 | 10/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.66 |
| ▸ | FER | P16591 | 5/20 | 0.66 |
| ▸ | BLK | P51451 | 5/20 | 0.66 |
| ▸ | STK3 | Q13188 | 5/20 | 0.66 |
| ▸ | RET | P07949 | 5/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.66 |
| ▸ | AURKA | O14965 | 5/20 | 0.66 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.66 |
| ▸ | FYN | P06241 | 5/20 | 0.66 |
| ▸ | MET | P08581 | 5/20 | 0.66 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.66 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.66 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.66 |
| ▸ | FLT1 | P17948 | 5/20 | 0.66 |
| ▸ | KIT | P10721 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17034027 | 1.00 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| SCHEMBL18579380 | 0.87 | KDR (0.76) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL3381224 | 0.79 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL29373142 | 0.79 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL29496449 | 0.79 | KDR (1.00) | KDRBTKFGFR1AURKBFER | |
| SCHEMBL5472344 | 0.79 | KDR (0.65) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL30406133 | 0.79 | KDR (0.98) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL11898929 | 0.79 | KDR (0.98) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL11900182 | 0.79 | KDR (0.94) | KDRBTKFGFR1AURKBFER | |
| Ilorasertib SCHEMBL11899788 | 0.79 | KDR (0.94) | KDRBTKFGFR1AURKBFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112351-B1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-03-30 | — | — | EP | disclosed |