Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.45 |
| ▸ | JAK3 | P52333 | 8/20 | 0.45 |
| ▸ | WEE1 | P30291 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CCND2 | P30279 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20035 | 0.92 | JAK2 (0.51) | JAK2JAK3WEE1PTK2MEN1 | |
| SCHEMBL16394451 | 0.80 | JAK2 (0.49) | JAK2JAK3PTK2MEN1KMT2A | |
| SCHEMBL15221144 | 0.79 | JAK2 (0.46) | JAK2JAK3PTK2KMT2AMAPT | |
| SCHEMBL15221157 | 0.79 | CA1 (0.52) | JAK2JAK3PTK2 | |
| SCHEMBL15221147 | 0.78 | CDK1 (0.52) | JAK2JAK3PTK2MAPK1GSK3A | |
| SCHEMBL21018 | 0.78 | NFKB1 (0.51) | JAK2JAK3PTK2MAPTNFKB1 | |
| SCHEMBL16394492 | 0.77 | JAK2 (0.63) | JAK2JAK3PTK2 | |
| SCHEMBL16394411 | 0.76 | SYK (0.55) | JAK2JAK3MEN1KMT2AUSP2 | |
| SCHEMBL15210382 | 0.76 | JAK2 (0.53) | JAK2JAK3PTK2MEN1KMT2A | |
| SCHEMBL19913 | 0.75 | JAK2 (0.50) | JAK2JAK3PTK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |
| US-9120804-B2 | 8-substituted 2-amino-[1,2,4] triazolo [1, 5-A] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors | MERCK PATENT GMBH (DE) | 2015-09-01 | — | — | US | disclosed |