SCHEMBL1703560

SCHEMBL1703560

COc1cc(C(O)C2C=CC3C(=O)N(c4ccccc4)C(=O)C3N2Nc2ccc([N+](=O)[O-])cc2)cc(OC)c1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PNKP Q96T60 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1703154 0.87 PNKP (0.88) PNKP
SCHEMBL17603648 0.82 PNKP (1.00) PNKP
SCHEMBL22683117 0.82 PNKP (1.00) PNKP
SCHEMBL22683134 0.82 PNKP (1.00) PNKP
SCHEMBL22000415 0.81 PNKP (0.84) PNKP
SCHEMBL22000583 0.78 PNKP (1.00) PNKP
SCHEMBL22000586 0.77 PNKP (0.74) PNKP
SCHEMBL22683120 0.76 PNKP (1.00) PNKP
SCHEMBL20512281 0.76 PNKP (1.00) PNKP
SCHEMBL22000575 0.76 PNKP (1.00) PNKP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635579-B1 SYNTHETIC LETHALITY IN CANCER UNIV ALBERTA (CA) 2020-11-25 EP claimed
US-10087448-B2 Synthetic lethality in cancer THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2018-10-02 US claimed
US-20160083732-A1 SYNTHETIC LETHALITY IN CANCER ALBERTA HEALTH SERVICES (CA) 2016-03-24 US claimed
US-9115406-B2 Synthetic lethality in cancer THE GOVENORS OF THE UNIVERSITY OF ALBERTA (CA) 2015-08-25 US claimed
US-9040551-B2 Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2015-05-26 US claimed
US-20130289095-A1 SYNTHETIC LETHALITY IN CANCER THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2013-10-31 US claimed
US-20120142721-A1 SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF ALBERTA HEALTH SERVICES (CA) 2012-06-07 US claimed
EP-2440203-A1 SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE. POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF The Governors Of The University Of Alberta (CA) 2012-04-18 EP claimed
WO-2010139069-A1 SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE. POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2010-12-09 WO claimed
EP-2635579-B1 SYNTHETIC LETHALITY IN CANCER UNIV ALBERTA (CA) 2020-11-25 EP disclosed
US-10087448-B2 Synthetic lethality in cancer THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2018-10-02 US disclosed
US-9694073-B2 Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2017-07-04 US disclosed
US-20160083732-A1 SYNTHETIC LETHALITY IN CANCER ALBERTA HEALTH SERVICES (CA) 2016-03-24 US disclosed
US-20150306219-A1 SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF ALBERTA HEALTH SERVICES (CA) 2015-10-29 US disclosed
US-9115406-B2 Synthetic lethality in cancer THE GOVENORS OF THE UNIVERSITY OF ALBERTA (CA) 2015-08-25 US disclosed
US-9040551-B2 Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2015-05-26 US disclosed
US-20130289095-A1 SYNTHETIC LETHALITY IN CANCER THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2013-10-31 US disclosed
US-20120142721-A1 SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF ALBERTA HEALTH SERVICES (CA) 2012-06-07 US disclosed