Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.66 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | CDC7 | O00311 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | PRKACA | P17612 | 3/20 | 0.47 |
| ▸ | CDK7 | P50613 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | PAK4 | O96013 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703043 | 0.90 | KDR (0.65) | KDRAURKBLRRK2FLT4ALK | |
| SCHEMBL1703336 | 0.86 | ALK (0.67) | KDRAURKBALKCDK19JAK3 | |
| SCHEMBL1703311 | 0.86 | JAK2 (0.64) | KDRAURKBFLT4ALKCDK19 | |
| SCHEMBL1703985 | 0.78 | CDK9 (0.61) | KDRFLT4ALKCDK19JAK3 | |
| SCHEMBL29706095 | 0.76 | KDR (0.93) | KDRAURKBLRRK2FLT4ALK | |
| SCHEMBL4560975 | 0.75 | LRRK2 (1.00) | KDRAURKBLRRK2JAK3JAK2 | |
| SCHEMBL14663564 | 0.75 | LRRK2 (0.65) | KDRAURKBLRRK2FLT4ALK | |
| SCHEMBL24393106 | 0.73 | LRRK2 (0.63) | KDRAURKBLRRK2ALKCDK19 | |
| SCHEMBL29537273 | 0.73 | LRRK2 (0.63) | KDRAURKBLRRK2ALKCDK19 | |
| SCHEMBL14663754 | 0.72 | LRRK2 (0.62) | KDRAURKBLRRK2FLT4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440548-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | Abbott Laboratories (US) | 2012-04-18 | — | — | EP | claimed |
| US-20100317680-A1 | PYRIMIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | US | claimed |
| WO-2010144468-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | claimed |
| US-8426408-B2 | Pyrimidine inhibitors of kinases | ABBVIE INC. (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2440548-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | Abbott Laboratories (US) | 2012-04-18 | — | — | EP | disclosed |
| US-20100317680-A1 | PYRIMIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | US | disclosed |
| WO-2010144468-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317680-A1 | PYRIMIDINE INHIBITORS OF KINASES | AURKA, AURKC, AURKB | KDR 38/4885AURKB 3/4885LRRK2 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.