Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008796 | 0.90 | TLR7 (0.48) | TLR7GRM2HDAC1HDAC2HDAC11 | |
| SCHEMBL1059384 | 0.90 | TLR7 (0.48) | TLR7GRM2HDAC1HDAC2HDAC11 | |
| SCHEMBL1009183 | 0.85 | TLR7 (0.46) | TLR7GRM2TDP1 | |
| SCHEMBL1527519 | 0.85 | TLR7 (0.64) | TLR7GRM2 | |
| SCHEMBL11891212 | 0.85 | TLR7 (0.64) | TLR7GRM2 | |
| SCHEMBL1057437 | 0.85 | TLR7 (0.47) | TLR7TLR8GRM2 | |
| SCHEMBL16735809 | 0.83 | TLR7 (0.45) | TLR7GRM2 | |
| SCHEMBL1056013 | 0.81 | TLR7 (0.47) | TLR7GRM2 | |
| SCHEMBL1009607 | 0.80 | TLR7 (0.46) | TLR7GRM2 | |
| SCHEMBL1527588 | 0.80 | TLR7 (0.65) | TLR7GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558069-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| EP-2440245-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | Novartis AG (CH) | 2012-04-18 | — | — | EP | disclosed |
| WO-2011130379-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-20 | — | — | WO | disclosed |
| WO-2010144734-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | NOVARTIS AG (CH) | 2010-12-16 | — | — | WO | disclosed |