Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863342 | 0.92 | HRH3 (0.49) | DRD2HTR2AHRH3KCNH2CYP2D6 | |
| SCHEMBL863277 | 0.84 | DRD2 (0.46) | DRD2HTR2AHRH3KCNH2CYP2D6 | |
| SCHEMBL3070795 | 0.83 | HRH3 (0.51) | DRD2HTR2AHRH3KCNH2CYP2D6 | |
| SCHEMBL10191861 | 0.83 | HRH3 (0.46) | HRH3KCNH2CYP2D6 | |
| SCHEMBL863955 | 0.83 | HRH3 (0.45) | HRH3KCNH2CYP2D6 | |
| SCHEMBL863842 | 0.80 | HRH3 (0.44) | HRH3KCNH2CYP2D6 | |
| SCHEMBL863687 | 0.80 | HRH3 (0.45) | HRH3KCNH2CYP2D6 | |
| SCHEMBL10191860 | 0.79 | HRH3 (0.44) | HRH3KCNH2CYP2D6 | |
| SCHEMBL863482 | 0.79 | DRD2 (0.41) | DRD2HTR2AHRH3 | |
| SCHEMBL10191856 | 0.79 | HRH3 (0.47) | HRH3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440563-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | Sunovion Pharmaceuticals Inc. (US) | 2012-04-18 | — | — | EP | disclosed |