Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26630556 | 0.86 | ROCK1 (0.38) | ROCK1LPLLIPGDGAT1HIF1A | |
| SCHEMBL17099424 | 0.86 | AAK1 (0.38) | PDK2DGAT1ABL1HIF1ACA1 | |
| SCHEMBL27096456 | 0.85 | PTGS2 (0.39) | PDK2DGAT1ABL1HIF1ACA1 | |
| SCHEMBL30673248 | 0.85 | ROCK1 (0.37) | ROCK1LPLLIPGDGAT1HIF1A | |
| SCHEMBL26928552 | 0.85 | ROCK1 (0.37) | ROCK1LPLLIPGDGAT1HIF1A | |
| SCHEMBL27433795 | 0.85 | ROCK1 (0.37) | ROCK1LPLLIPGDGAT1HIF1A | |
| SCHEMBL16962901 | 0.85 | ROCK1 (0.39) | ROCK1LPLLIPGCA1CA2 | |
| SCHEMBL29155208 | 0.84 | ROCK1 (0.37) | ROCK1LPLLIPGDGAT1HIF1A | |
| SCHEMBL515152 | 0.81 | ROCK1 (0.40) | ROCK1LPLLIPGDGAT1HIF1A | |
| SCHEMBL6892735 | 0.81 | ROCK1 (0.37) | ROCK1LPLLIPGDGAT1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152239-A1 | BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS | PFIZER INC. (US) | 2017-06-01 | — | — | US | disclosed |
| US-20170152239-A1 | BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS | PFIZER INC. (US) | 2017-06-01 | — | — | US | disclosed |
| US-20150239842-A1 | BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS | PFIZER INC. (US) | 2015-08-27 | — | — | US | disclosed |
| US-20150239842-A1 | BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS | PFIZER INC. (US) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239842-A1 | BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS | HRH2, H1-0, H1-2 | ROCK1 3899/4885PDK2 1375/4885LPL 3857/4885 |
| US-20170152239-A1 | BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS | HRH2, HRH4, H1-0 | ROCK1 3967/4885PDK2 1460/4885LPL 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.