Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17038748 | 0.90 | POLB (0.47) | ALDH1A1MAPTSMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL17039011 | 0.90 | POLB (0.55) | ALDH1A1MAPTSMN1; SMN2MAPK1HIF1A | |
| SCHEMBL17195592 | 0.87 | SMN1; SMN2 (0.56) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL17038861 | 0.86 | SMN1; SMN2 (0.48) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL17039014 | 0.85 | POLB (0.52) | MAPTHIF1AEPAS1POLBRXFP1 | |
| SCHEMBL17039017 | 0.85 | MEN1 (0.52) | ALDH1A1MAPTSMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL17038740 | 0.84 | GRM4 (0.52) | ALDH1A1MAPTSMN1; SMN2GAAHTR6 | |
| SCHEMBL17039026 | 0.84 | HDAC6 (0.55) | MAPTHIF1AEPAS1POLBHTR6 | |
| SCHEMBL17039007 | 0.83 | RXFP1 (0.49) | ALDH1A1MAPTLMNAHIF1AEPAS1 | |
| SCHEMBL17039018 | 0.83 | MAPT (0.48) | ALDH1A1MAPTSMN1; SMN2LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858929-B2 | Compounds and methods for inhibiting fascin | CORNELL UNIVERSITY (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230310378-A1 | CO-THERAPIES INCLUDING A METASTASIS INHIBITOR | NOVITA PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | US | disclosed |
| US-11701342-B2 | Co-therapies including a metastasis inhibitor | CORNELL UNIVERSITY (US) | 2023-07-18 | — | — | US | disclosed |
| US-20210340138-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | NOVITA PHARMACEUTICALS, INC. | 2021-11-04 | — | — | US | disclosed |
| EP-3107902-B1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | CORNELL UNIV CORNELL CENTER FOR TECHNOLOGY ENTERPRISE & COMMERCIALIZATION CCTEC (US) | 2021-04-07 | — | — | EP | disclosed |
| US-10941141-B2 | Compounds and methods for inhibiting fascin | NOVITA PHARMACEUTICALS, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| US-20200352911-A1 | CO-THERAPIES INCLUDING A METASTASIS INHIBITOR | CORNELL UNIVERSITY | 2020-11-12 | — | — | US | disclosed |
| US-20200039976-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | CORNELL UNIVERSITY | 2020-02-06 | — | — | US | disclosed |
| WO-2019104067-A1 | CO-THERAPIES INCLUDING A METASTASIS INHIBITOR | CORNELL UNIVERSITY (US) | 2019-05-31 | — | — | WO | disclosed |
| US-10227345-B2 | Compounds and methods for inhibiting fascin | CORNELL UNIVERSITY (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180215757-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | CORNELL UNIVERSITY | 2018-08-02 | — | — | US | disclosed |
| US-9850243-B2 | Compounds and methods for inhibiting fascin | NOVITA PHARMACEUTICALS, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170158692-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | CORNELL UNIVERSITY | 2017-06-08 | — | — | US | disclosed |
| US-9573946-B2 | Compounds and methods for inhibiting fascin | NOVITA PHARMACEUTICALS, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| WO-2015127125-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | CORNELL UNIVERSITY (US) | 2015-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227345-B2 | Compounds and methods for inhibiting fascin | FSCN1, MTPN, MYOF | ALDH1A1 3976/4885MAPT 352/4885SMN1; SMN2 35/4885 |
| US-20210340138-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | FSCN1, MTPN, MYOF | ALDH1A1 3976/4885MAPT 352/4885SMN1; SMN2 35/4885 |
| US-11858929-B2 | Compounds and methods for inhibiting fascin | FSCN1, MTPN, MYOF | ALDH1A1 3976/4885MAPT 352/4885SMN1; SMN2 35/4885 |
| US-20230310378-A1 | CO-THERAPIES INCLUDING A METASTASIS INHIBITOR | MIF, CXCL10, CCL2 | ALDH1A1 1799/4885MAPT 1951/4885SMN1; SMN2 3159/4885 |
| US-20180215757-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | FSCN1, MTPN, MYOF | ALDH1A1 3976/4885MAPT 352/4885SMN1; SMN2 35/4885 |
| US-20200352911-A1 | CO-THERAPIES INCLUDING A METASTASIS INHIBITOR | MIF, CXCL10, CCL2 | ALDH1A1 1799/4885MAPT 1951/4885SMN1; SMN2 3159/4885 |
| US-20170158692-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | FSCN1, MTPN, MYOF | ALDH1A1 3976/4885MAPT 352/4885SMN1; SMN2 35/4885 |
| US-11701342-B2 | Co-therapies including a metastasis inhibitor | MIF, CXCL10, CCL2 | ALDH1A1 1799/4885MAPT 1951/4885SMN1; SMN2 3159/4885 |
| US-10941141-B2 | Compounds and methods for inhibiting fascin | FSCN1, MTPN, MYOF | ALDH1A1 3976/4885MAPT 352/4885SMN1; SMN2 35/4885 |
| US-20200039976-A1 | COMPOUNDS AND METHODS FOR INHIBITING FASCIN | FSCN1, MTPN, MYOF | ALDH1A1 3976/4885MAPT 352/4885SMN1; SMN2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.