Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898393 | 1.00 | ALK (0.48) | ALKNTRK1LCKKDR | |
| SCHEMBL20004790 | 0.89 | ALK (0.55) | ALK | |
| SCHEMBL898127 | 0.88 | ALK (0.58) | ALK | |
| SCHEMBL897766 | 0.86 | NTRK1 (0.48) | ALKNTRK1LCKKDR | |
| SCHEMBL896552 | 0.85 | ALK (0.46) | ALKNTRK1 | |
| SCHEMBL898394 | 0.84 | ALK (0.46) | ALK | |
| SCHEMBL898405 | 0.83 | ALK (0.46) | ALKNTRK1 | |
| SCHEMBL898392 | 0.83 | ALK (0.44) | ALK | |
| SCHEMBL1704004 | 0.83 | ALK (0.44) | ALK | |
| SCHEMBL897592 | 0.81 | ALK (0.45) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |