Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 12/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.64 |
| ▸ | THPO | P40225 | 3/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | MTOR | P42345 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17037453 | 0.91 | DRD1 (0.61) | DRD1HSD17B10THPOHIF1AMTOR | |
| SCHEMBL11528134 | 0.81 | DRD1 (0.64) | DRD1HSD17B10THPOHIF1AMTOR | |
| SCHEMBL11712694 | 0.78 | DRD1 (1.00) | DRD1HSD17B10THPOHIF1AMTOR | |
| Bromide SCHEMBL11707024 | 0.77 | KDM4E (1.00) | DRD1HSD17B10THPOHIF1AMTOR | |
| SCHEMBL7625264 | 0.76 | DRD1 (0.54) | DRD1HSD17B10THPOHIF1AMTOR | |
| Bromide SCHEMBL11539891 | 0.74 | KDM4E (0.72) | DRD1HSD17B10THPOHIF1AMTOR | |
| Bromide SCHEMBL11721722 | 0.72 | KDM4E (0.71) | DRD1HSD17B10THPOHIF1AMTOR | |
| SCHEMBL11157379 | 0.72 | DRD1 (0.70) | DRD1HSD17B10THPOHIF1AMTOR | |
| Hydrochloric Acid SCHEMBL11463952 | 0.71 | DRD1 (0.71) | DRD1HSD17B10THPOHIF1AMTOR | |
| Bromide SCHEMBL11712496 | 0.71 | KDM4E (0.68) | DRD1HSD17B10THPOHIF1AMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, TYRO3 | DRD1 3704/4885HSD17B10 3844/4885THPO 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.