Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.73 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902626 | 0.95 | KARS1 (0.73) | KARS1CKS1BSKP1SKP2GPR119 | |
| SCHEMBL1705312 | 0.95 | KARS1 (0.73) | KARS1GPR119DYRK1ASYKTBK1 | |
| SCHEMBL902673 | 0.94 | KARS1 (0.65) | KARS1CKS1BSKP1SKP2PTPN11 | |
| SCHEMBL1704267 | 0.93 | KARS1 (0.63) | KARS1GPR119DYRK1ASYKTBK1 | |
| SCHEMBL901379 | 0.93 | KARS1 (0.64) | KARS1GPR119DYRK1ASYKTBK1 | |
| SCHEMBL1704942 | 0.93 | KARS1 (0.64) | KARS1GPR119SYKTBK1 | |
| SCHEMBL1704600 | 0.93 | KARS1 (0.73) | KARS1GPR119DYRK1ASYKTBK1 | |
| SCHEMBL903001 | 0.92 | KARS1 (0.62) | KARS1GPR119DYRK1ASYKTBK1 | |
| SCHEMBL1704921 | 0.92 | KARS1 (0.63) | KARS1GPR119SYKTBK1 | |
| SCHEMBL1705003 | 0.92 | KARS1 (0.65) | KARS1GPR119DYRK1ASYKTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |