Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32348 | 0.85 | — | — | |
| Methacrylic Acid SCHEMBL28144488 | 0.84 | TET2 (0.31) | — | |
| Formic Acid SCHEMBL27851458 | 0.81 | — | — | |
| Bicarbonate SCHEMBL8829543 | 0.79 | TP53 (0.37) | TP53ALDH1A1 | |
| SCHEMBL25186548 | 0.76 | THRB (0.39) | TP53ALDH1A1L3MBTL1 | |
| SCHEMBL1766344 | 0.72 | — | — | |
| Acetic Acid SCHEMBL28380342 | 0.72 | FFAR3 (0.39) | — | |
| SCHEMBL1766346 | 0.72 | TP53 (0.38) | TP53 | |
| SCHEMBL22501467 | 0.72 | — | — | |
| SCHEMBL6514807 | 0.72 | THRB (0.46) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440518-B1 | METHOD FOR MAKING FLUOROALKYL NITRILES | BAYER CROPSCIENCE AG (DE) | 2014-08-20 | — | — | EP | claimed |
| EP-2245001-B1 | Method for the production of 2-fluoroacyl-3-amino-acrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-2440518-A1 | METHOD FOR PRODUCING FLUOROALKYL NITRILES | Bayer Cropscience AG (DE) | 2012-04-18 | — | — | EP | claimed |
| WO-2010142377-A1 | METHOD FOR PRODUCING FLUOROALKYL NITRILES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-12-16 | — | — | WO | claimed |
| EP-2245001-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-11-03 | — | — | EP | claimed |
| WO-2009083134-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-07-09 | — | — | WO | claimed |
| EP-2072497-A1 | Method for manufacturing 2-fluoracyl-3-amino-acrylic acid derivatives | Bayer CropScience AG (DE) | 2009-06-24 | — | — | EP | claimed |
| EP-2440518-B1 | METHOD FOR MAKING FLUOROALKYL NITRILES | BAYER CROPSCIENCE AG (DE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2245001-B1 | Method for the production of 2-fluoroacyl-3-amino-acrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-03-20 | — | — | EP | disclosed |
| EP-2440518-A1 | METHOD FOR PRODUCING FLUOROALKYL NITRILES | Bayer Cropscience AG (DE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142377-A1 | METHOD FOR PRODUCING FLUOROALKYL NITRILES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-12-16 | — | — | WO | disclosed |
| EP-2245001-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009083134-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-07-09 | — | — | WO | disclosed |
| EP-2072497-A1 | Method for manufacturing 2-fluoracyl-3-amino-acrylic acid derivatives | Bayer CropScience AG (DE) | 2009-06-24 | — | — | EP | disclosed |