Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17044092 | 0.84 | KDR (0.41) | RIPK2RETKDRMAPK14PKMYT1 | |
| SCHEMBL17044055 | 0.84 | PKMYT1 (0.48) | GAAMAPTMAPKAPK2RIPK2RET | |
| SCHEMBL17044067 | 0.83 | KDM4E (0.44) | RIPK2PTGS1PTGDR2 | |
| SCHEMBL17044074 | 0.83 | RIPK2 (0.50) | RIPK2KDRPTGS1AURKAEGFR | |
| SCHEMBL17044080 | 0.83 | GRM4 (0.43) | RIPK2PTGS1PTK6PTGDR2 | |
| SCHEMBL17044100 | 0.83 | GRM4 (0.44) | RIPK2PTGS1EGFRPTK6HTR1A | |
| SCHEMBL17044114 | 0.83 | RET (0.60) | RIPK2RETKDRMAPK14PKMYT1 | |
| SCHEMBL17044064 | 0.83 | RIPK2 (0.49) | GAAALDH1A1MAPTRIPK2RET | |
| SCHEMBL17044085 | 0.82 | KDR (0.46) | RIPK2RETKDRMAPK14PKMYT1 | |
| SCHEMBL17044063 | 0.82 | KDR (0.46) | ALDH1A1RIPK2RETKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | claimed |