Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.54 |
| ▸ | LPL | P06858 | 6/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14366710 | 0.88 | LIPG (0.50) | LIPGLPLPRMT5WDR77AAK1 | |
| SCHEMBL10733 | 0.86 | LIPG (0.58) | LIPGLPLHIF1ADGAT1AKR1C3 | |
| SCHEMBL13239269 | 0.85 | LIPG (0.54) | LIPGLPLPRMT5WDR77AAK1 | |
| SCHEMBL2823269 | 0.84 | LIPG (0.59) | LIPGLPLHIF1AAKR1C3AKR1C2 | |
| SCHEMBL2144320 | 0.82 | LIPG (0.51) | LIPGLPLPRMT5WDR77AAK1 | |
| SCHEMBL901322 | 0.82 | LIPG (0.74) | LIPGLPLF2F11PRSS1 | |
| SCHEMBL13739884 | 0.82 | PRMT5 (0.42) | LIPGLPLPRMT5WDR77AAK1 | |
| SCHEMBL1802895 | 0.81 | LIPG (0.55) | LIPGLPLPRMT5WDR77AAK1 | |
| SCHEMBL28810425 | 0.81 | LIPG (0.51) | LIPGLPLPRMT5WDR77AAK1 | |
| SCHEMBL23544352 | 0.80 | PRMT5 (0.42) | LIPGLPLPRMT5WDR77AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |