Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 8/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704494 | 1.00 | NOTUM (0.44) | NOTUMDGAT2PDGFRBFGFR1KDR | |
| SCHEMBL1284182 | 0.91 | DGAT2 (0.42) | NOTUMDGAT2ATR | |
| SCHEMBL1284181 | 0.91 | DGAT2 (0.42) | NOTUMDGAT2ATR | |
| SCHEMBL1625621 | 0.91 | DGAT2 (0.42) | NOTUMDGAT2ATR | |
| SCHEMBL1283949 | 0.89 | ATR (0.46) | NOTUMDGAT2PDGFRBFGFR1KDR | |
| SCHEMBL1283946 | 0.89 | ATR (0.46) | NOTUMDGAT2PDGFRBFGFR1KDR | |
| SCHEMBL1283734 | 0.89 | ATR (0.43) | NOTUMDGAT2PDGFRBFGFR1KDR | |
| SCHEMBL1284155 | 0.89 | ATR (0.46) | NOTUMDGAT2PDGFRBFGFR1KDR | |
| SCHEMBL1624030 | 0.89 | DGAT2 (0.45) | NOTUMDGAT2ATRMAPT | |
| SCHEMBL1625258 | 0.89 | DGAT2 (0.45) | NOTUMDGAT2ATRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440544-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND THERAPEUTIC APPLICATIONS THEREOF | Siena Biotech S.p.A. (IT) | 2012-04-18 | — | — | EP | claimed |
| WO-2010142426-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND THERAPEUTIC APPLICATIONS THEREOF | SIENA BIOTECH S.P.A. (IT) | 2010-12-16 | — | — | WO | claimed |